EHT and Caffeine – Brain Protection Duo

Drinking coffee reduces the risk of Parkinson’s Disease, but scientists didn’t know exactly how or why. UNTIL NOW! A study by Rutgers University scientists discovered that caffeine and something in the waxy coating of coffee beans (let’s just call it “EHT” for short) work as a dynamic duo to protect the brain.

Caffeine and EHT = Brain Protection Duo
REF: Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson’s disease and DLB https://doi.org/10.1073/pnas.1813365115

SCIENCE TRANSLATION:

With Parkinson’s disease and one type of dementia, there’s this clutter that builds up in the brain. This clutter has the Gemino Curse/Doubling Charm (Harry Potter Reference!) and starts taking up way too much space so the brain can’t work right. One way to stop this clutter from expanding is a machine called PP2A. Caffeine and EHT know how to turn on this PP2A machine, thus minimizing the increase of the clutter.

Harry Potter and the Gemino Curse
Harry Potter and the Gemino Curse

THE SCIENCE:

With Parkinson’s disease and Lewy body dementia, a protein called alpha-synuclein accumulates as abnormal aggregates in the brain. This protein is modified by a process called phosphorylation, which adds a phosphate group to the protein. To protect the brain, the goal is to minimize this phosphorylation. Protein phosphatase 2A (PP2A) is an enzyme that removes the phosphate group. Caffeine and EHT (eicosanoyl-5-hydroxytryptamide) enhance the activity of PP2A.

alpha-synuclein and Parkinsons Disease
From “The role of α-synuclein in Parkinson’s disease: insights from animal models” Nature Reviews Neuroscience volume 4, pages 727–738 (2003)

REFERENCE:

  • Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson’s disease and DLB
    • https://doi.org/10.1073/pnas.1813365115
  • IFT NEXT Newsletter, “Coffee compounds join forces to fight Parkinson’s

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Drinking coffee reduces the risk of Parkinson's Disease, but scientists didn't know exactly how or why. UNTIL NOW! A study by Rutgers University scientists discovered that caffeine and something in the waxy coating of coffee beans (let's just call it "EHT" for short) work as a dynamic duo to protect the brain. SCIENCE TRANSLATION: With Parkinson's disease and one type of dementia, there's this clutter that builds up in the brain. This clutter has the Gemino Curse/Doubling Charm (Harry Potter Ref!) and starts taking up way too much space so the brain can't work right. One way to stop this clutter from expanding is a machine called PP2A. Caffeine and EHT know how to turn on this PP2A machine, thus minimizing the increase of the clutter. THE SCIENCE: With Parkinson’s disease and Lewy body dementia, a protein called alpha-synuclein accumulates as abnormal aggregates in the brain. This protein is modified by a process called phosphorylation, which adds a phosphate group to the protein. To protect the brain, the goal is to minimize this phosphorylation. Protein phosphatase 2A (PP2A) is an enzyme that removes the phosphate group. Caffeine and EHT (eicosanoyl-5-hydroxytryptamide) enhance the activity of PP2A. [REF: https://doi.org/10.1073/pnas.1813365115] #caffeinescience #coffee #pp2a #parkinsonsdisease #dementia #eht #harrypotter #obscureharrypotterreference

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